Turning T Cell immunology on its head—5 October 2015

Challenging a universally accepted, longstanding consensus in the field of immunity requires hard evidence—and new research from the ARC Centre of Excellence in Advanced Molecular Imaging has shown the proof is in the picture. This proof may have implications for type 1 diabetes. Until now, the assumption has been that the receptors on white blood cells (TCRs) must bind to immune molecules in a specific orientation in order to trigger a signal to the immune system. A team of researchers at the Centre, led by Monash University’s Professor Jamie Rossjohn, has succeeded in turning current immunology on its head, demonstrating for the first time that TCRs can bind with a completely reversed orientation—compared to all previously studied receptors.

Media issued by the ARC Centre for Advanced Molecular Imaging.

Image: Paper with Words Diabetes Type 1.
Image courtesy: Dreamstime.com stock free images.

Original Published Date: 
Monday, October 5, 2015