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The molecular heart of celiac disease revealed

The molecular heart of celiac disease revealed

Media issued by Science in Public

Researchers at the new ARC Centre of Excellence in Advanced Molecular Imaging have discovered how immune cells bind to wheat proteins that trigger celiac disease.

They have described the molecular basis of how most of the immune cells (T cells) that induce celiac disease lock onto gliadin, a component of gluten, thereby triggering inflammation of the lining of the small intestine. This is what gives many celiac sufferers symptoms similar to food poisoning after eating a slice of toast.

The work opens the way to potential treatments and diagnostics.

Image Credit: Mariana Kurnyk Pexels

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